The purposes of the experiments conducted within this paper are: 1) to successfully synthesize a compound that is inherent to over fifty percent of a library obtained from Find-A-Drug, 2) to attempt to make a Ugi product, 3) to monitor imine reversal and the technique to prevent reversal, and 4) to conduct research in an Open Source manner via Wikis and Blogs. The successful synthesis of the particular compound DOPAL was required because it is not readily commercially available. Compounds thought to inhibit enoyl reductase, an enzyme utilized by malarial parasites, were obtained from Find-A-Drug in a library of 250 possible diketopiperazines. This research is unbarred from normal constraints of laboratory research in order to promote public discussion of experiments, results, theories and hypothesis so ideas stay fresh. To do this, experimental results have been published on this wiki for free viewing. For example, NMR spectra were saved in JCAMP format and, utilizing a program developed by Robert Lancashire, uploaded onto a Drexel server and linked to on the main experiment wiki page.
Synthesizing DOPAL, working the Ugi Reaction, and
Open Source Science
Abstract
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Introduction